The Need to Improve CABG Surgery
Heart Disease is the leading cause of death in the US
CABG surgery is the only appropriate method of coronary revascularization for patients with triple vessel disease.1
Surgery is needed to restore blood flow by implanting grafts to bypass blockages
During CABG surgery, a blood vessel is removed or redirected from one area of the body and implanted to provide blood flow downstream to an area of obstruction in the coronary artery. This vessel, called a graft, bypasses the blockage and restores blood flow to the heart muscle.
Saphenous veins are the most commonly used bypass graft
However, saphenous veins are limited in their ability to withstand the blood pressure in the arterial system. Saphenous vein graft disease is progressive, with failure as high as 50% at 10 years2,3. This can lead to potentially costly and complicated reinterventions, compromised quality of life, or death.
The Opportunity to Improve CABG Surgery
Number of CABG surgeries conducted each year globally
In 2010, there were 395,000 CABG surgeries in the United States4 alone, and it is estimated there were 165,000 CABG procedures in Europe in 2013.5
The left internal mammary artery is a preferred conduit
The average number of blockages bypassed during a procedure is 3.5 and one of these is almost always performed using the left internal mammary artery.6 Although other arteries are sometimes used as bypass grafts, the average number of saphenous vein grafts used in a CABG procedure is 2+.
Potential market size
Moderate growth in CABG procedures is expected in the United States.
1 American Heart Association
2Sabik JF 3rd, Lytle BW, Blackstone EH, Houghtaling PL, Cosgrove DM. Comparison of saphenous vein and internal thoracic artery graft patency by coronary system. Ann Thorac Surg 2005; 79:544 –51.
3Bourassa MG, Fisher LD, Campeau L, Gillespie MJ, McConney M, Lesperance J. Long-term fate of bypass grafts: the Coronary Artery Surgery Study (CASS) and Montreal Heart Institute experiences. Circulation 1985;72:V71– 8.
4 CDC/NCHS National Hospital Discharge Survey, 2010
5 http://www.prnewswire.com/news-releases/clinical-data–innovation-will-shift-pci-and-cabg-procedures-in-europe-61862782.html
6 European Journal of Cardio-Thoracic Surgery, 2009
2Sabik JF 3rd, Lytle BW, Blackstone EH, Houghtaling PL, Cosgrove DM. Comparison of saphenous vein and internal thoracic artery graft patency by coronary system. Ann Thorac Surg 2005; 79:544 –51.
3Bourassa MG, Fisher LD, Campeau L, Gillespie MJ, McConney M, Lesperance J. Long-term fate of bypass grafts: the Coronary Artery Surgery Study (CASS) and Montreal Heart Institute experiences. Circulation 1985;72:V71– 8.
4 CDC/NCHS National Hospital Discharge Survey, 2010
5 http://www.prnewswire.com/news-releases/clinical-data–innovation-will-shift-pci-and-cabg-procedures-in-europe-61862782.html
6 European Journal of Cardio-Thoracic Surgery, 2009